采用直接压片法制备了以卡波姆为骨架材料的磷酸川芎嗪缓释片。其体外释放曲线 12 h内符合 Higuchi方程 ,2～ 8h内接近零级。药物释放速率随卡波姆用量增多而减慢 ,并受卡波姆类型、释药介质 p H的影响。 The sustained release tablets of ligustrazine phosphate with carbomer as the framework material were prepared by direct compression method. The in vitro release curve was within Higuchi’s equation within 12 h, and close to zero within 2 ~ 8 h. The rate of drug release slowed down with the increase of carbomer dosage and was influenced by carbomer type and p H release medium.