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目的观察急性脑出血疾病并发意识障碍患者临床特点,提出治疗措施并评价临床疗效。方法回顾性分析郸城县中医院神经内科2012年9月至2013年9月期间收治的88例急性脑血管疾病合并意识障碍患者临床资料,随机双盲法分为2组,其中对照组患者采取传统常规方式进行治疗,研究组在常规治疗基础上合用纳洛酮进行治疗,比较两组不同治疗方法的临床效果及神经功能(GOS)、意识障碍恢复情况(GCS)。结果研究组治疗后GCS评分上升幅度大于对照组(P<0.05),且神经功能恢复良好率显著优于对照组(P<0.05)。经治疗后随访,研究组总有效率为97.7%,显著高于对照组的81.8%,2组比较差异具有统计学意义(P<0.05);且研究组患者未见明显并发症发生,仅发生较轻的呕吐和恶心,对照组患者发生不同程度的肝肾脏器功能损害。结论采取传统常规方法联合应用纳洛酮对急性脑血管疾病合并意识障碍患者临床效果较佳,且具有安全有效,并发症少等优点,因此该方法值得在临床推广应用。
Objective To observe the clinical features of patients with acute cerebral hemorrhage complicated by congenital disorders, to propose treatment measures and to evaluate the clinical efficacy. Methods The clinical data of 88 patients with acute cerebrovascular disease complicated with impaired consciousness admitted in Department of Neurology, Dancheng Hospital of Traditional Chinese Medicine from September 2012 to September 2013 were retrospectively analyzed. Randomized double-blind method was divided into two groups, in which the control group patients The traditional method was used to treat the patients. The study group was treated with naloxone on the basis of routine treatment. The clinical effects, neurological function (GOS) and recovery of disturbance of consciousness (GCS) were compared between the two groups. Results The GCS score increased more significantly in the study group than in the control group (P <0.05), and the recovery rate of neurological function was significantly better than that of the control group (P <0.05). After treatment, the total effective rate in the study group was 97.7%, which was significantly higher than that in the control group (81.8%). The difference between the two groups was statistically significant (P <0.05); and no significant complication occurred in the study group and only occurred Lighter vomiting and nausea, the control group of patients with varying degrees of liver and kidney dysfunction. Conclusion The traditional method combined with naloxone in patients with acute cerebrovascular disease complicated by disturbance of consciousness has better clinical effect, and has the advantages of safe and effective, less complications, so the method deserves clinical application.