文章简介慢性疼痛可导致焦虑,焦虑能增强痛觉。不幸的是,对这些现象的关联的基本神经机制了解很少。在这篇文章里,研究发现了和痛/焦虑相关的ACC有两种完全不同的长期可塑性(LTP):突触前和突触后。突触前LTP需要有腺苷酸环化酶和蛋白激酶A的参与,而它的表达是通过一种机制涉及超极化激活环核苷酸门控通道(HCN)。有趣的是,慢性疼痛和焦虑都能选择性抑制突触前LTP。更重要的,将HCN的阻滞剂 About the article Chronic pain can lead to anxiety, anxiety can increase pain perception. Unfortunately, little is known about the underlying neural mechanisms for the association of these phenomena. In this article, we found two distinct types of long-term plasticity (LTP) associated with pain / anxiety-associated ACC: presynaptic and postsynaptic. The presynaptic LTP requires the involvement of adenylyl cyclase and protein kinase A, and its expression is through a mechanism that involves hyperpolarization-activated cyclic nucleotide gated channels (HCNs). Interestingly, both chronic pain and anxiety selectively inhibit presynaptic LTP. More importantly, HCN blockers