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血小板反应蛋白(TSP)是一种重要的细胞外基质糖蛋白,包括TSP-1、TSP-2、TSP-3、TSP-4和软骨寡聚基质蛋白/TSP-5五种类型。其中TSP-1由血小板α颗粒、成纤维细胞、血管内皮细胞等分泌,在病理及生理情况下可发挥多种生物学作用(如抑制血管内皮细胞增殖和迁移、促进血小板激活和聚集等),且与多种疾病的发生、发展密切相关。近年来,TSP-1在多种肾脏疾病中的作用日益引起人们的关注。
Thrombospondin (TSP) is an important extracellular matrix glycoprotein, including five types of TSP-1, TSP-2, TSP-3, TSP-4 and cartilage oligomeric matrix protein / TSP-5. TSP-1 is secreted by platelet α-granules, fibroblasts and vascular endothelial cells and plays a variety of biological roles in pathology and physiology (such as inhibition of proliferation and migration of vascular endothelial cells, promotion of platelet activation and aggregation, etc.) And with a variety of diseases, the development is closely related. In recent years, the role of TSP-1 in various kidney diseases has drawn increasing attention.