铅暴露男性精子功能和脂质过氧化评价

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该研究人群包括健康、有生育力的锌和铅金属制造业的工人。铅暴露的工人分成2组:中度铅暴露组和重度铅暴露组。对照组为无职业性铅暴露史的机关工作人员。检测血液和精浆中铅、镉和锌水平,血中锌原卟啉,尿中δ-氨基乙酰丙酸,精浆中丙二醛;并进行精子分析。研究人群的血液和精浆中镉和锌浓度无差异。与对照组相比,重度铅暴露组的丙二醛浓度(反映脂质过氧化)显著升高了约56%,而1h后的活动精子数减少了约34%。其他精子分析参数与铅暴露参数之间以及血液和精浆中铅、镉和锌浓度之间均无统计学相关性。铅中毒参数(血铅浓度、血中锌原卟啉、精浆铅浓度)与精浆丙二醛浓度之间有正相关性,而与精子活动力(血铅浓度、血中锌原卟啉)呈负相关性。丙二醛浓度的增加伴随着精子活动力的下降。总之,铅暴露,尤其是血铅浓度超过400μg/L时,导致男性精子活动力降低,其可能的原因是脂质过氧化的增加。 The study population included healthy and fertile workers in zinc and lead metal manufacturing. Workers exposed to lead were divided into two groups: moderate lead exposure and severe lead exposure. The control group was a staff member with no history of occupational exposure to lead. The levels of lead, cadmium and zinc in blood and seminal plasma, zinc protoporphyrin in blood, δ-aminolevulinic acid in urine, and malondialdehyde in seminal plasma were measured. Sperm analysis was performed. There was no difference in concentrations of cadmium and zinc between the study population and the seminal plasma. Compared with the control group, the concentration of malondialdehyde in severe lead exposure group (reflecting lipid peroxidation) increased significantly by about 56%, while the number of motile sperm decreased by about 34% after 1 hour. There was no statistical correlation between other sperm analysis parameters and lead exposure parameters, and between lead and cadmium and zinc concentrations in blood and seminal plasma. There was a positive correlation between lead poisoning parameters (blood lead concentration, protoporphyrin in blood, lead concentration in seminal plasma) and plasma concentration of malondialdehyde, but not with sperm motility (blood lead concentration, protoporphyrin ) Was negatively correlated. Increased concentrations of malondialdehyde accompanied by decreased sperm motility. In short, lead exposure, especially when the blood lead concentration exceeds 400 μg / L, leads to decreased sperm motility in men, possibly due to an increase in lipid peroxidation.
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