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目的:研究治疗剂量的三氧化二砷(ATO)注射液引起大鼠周围神经损伤的病理学演变,为临床安全、合理应用三氧化二砷注射液提供依据。方法:用ATO注射液给大鼠腹腔注射,观察不同时间段大鼠周围神经光镜下组织学及透射电镜下超微结构的变化及其演变。结果:实验组:30天神经滋养血管不同程度充血扩张、神经元细胞内尼氏体轻度减少,线粒体絮状、空泡变性;60天神经纤维轴索变性和节段性脱髓鞘明显;90天神经纤维轴索变性和节段性脱髓鞘部分恢复、滋养血管扩张明显减轻、尼氏体明显恢复、胞质内线粒体变性部分恢复。结论:治疗性ATO注射液引起的周围神经损伤的病理变化发生率较高,其程度较轻微,但其持续时间较长、恢复缓慢。
OBJECTIVE: To study the pathological changes of peripheral nerve injury induced by arsenic trioxide (ATO) in rats at therapeutic doses and provide the basis for clinical safe and rational application of arsenic trioxide injection. Methods: The rats were injected intraperitoneally with ATO injection to observe the changes of ultrastructure and the changes of ultrastructure under the light microscope of peripheral nerve in different time periods. Results: In the experimental group, the neurovascular vessels at 30 days were hyperemicuced and expanded, the Nissl bodies in the neurons were mildly reduced, the mitochondria were flocculent and vacuolar degeneration. The neurofibrillary degeneration and segmental demyelination were obvious at 60 days. 90 days axonal degeneration and segmental demyelination part of the recovery, nourish the vasodilation significantly reduced, significant recovery of Nisshin, mitochondrial degeneration within the cytoplasm partially restored. CONCLUSION: The incidence of peripheral nerve injury caused by ATO injection is higher than that of ATO injection, but its duration is longer and recovery is slower.