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目的:研究人类乳头瘤病毒(HPV)检测在宫颈癌、宫颈癌前病变及宫颈炎患者中的临床鉴别价值。方法:选取2013年5月到2015年5月我院确诊的宫颈病变临床资料320例,根据病理诊断结果将患者分为宫颈癌组(59例)、癌前病变组(138例)以及宫颈炎组(123例),检测并比较三组HPV阳性检出率、HPV相对含量以及HPV-DNA亚型情况。结果:宫颈炎组HPV阳性检出率、HPV相对含量及HPV-DNA各亚型阳性率均显著低于癌前病变组和宫颈癌组,且癌前病变组均显著低于宫颈癌组,比较差异具有统计学意义(P<0.05)。结论:HPV有助于鉴别宫颈癌、宫颈癌前病变及宫颈炎,对宫颈病变治疗和预后具有评价作用。
Objective: To study the clinical value of human papillomavirus (HPV) detection in cervical cancer, cervical precancerous lesions and cervicitis. Methods: The clinical data of 320 cases of cervical lesions diagnosed in our hospital from May 2013 to May 2015 were selected and divided into cervical cancer group (59 cases), precancerous lesions group (138 cases) and cervicitis (123 cases). The positive rate of HPV, relative content of HPV and HPV-DNA subtypes in three groups were detected and compared. Results: The positive rate of HPV, the relative content of HPV and the positive rate of HPV-DNA in cervicitis group were significantly lower than those in precancerous lesions group and cervical cancer group, and were significantly lower than those in cervical cancer group The difference was statistically significant (P <0.05). Conclusion: HPV can help identify cervical cancer, precancerous lesions of cervix and cervicitis, and has an evaluation on the treatment and prognosis of cervical lesions.