本文综述了两种细胞因子联合应用效果的实验和临床研究进展。在小鼠和猴IL-3,IL-6和IL-11与G-CSF,GM-CSF,SCF或Tpo联用促进造血恢复的效果比单因子好,而对晚期肿瘤或高恶性肉瘤的病人以及实体瘤的儿童来说,IL-3+GM-CSF和IL-6+G-CSF联用的临床效果尚不尽人意,且毒副作用明显。因此,要获得较理想的联合应用效果,还需要对联用时的适应证和剂量等因素给予慎密的研究。 This review summarizes the experimental and clinical research advances in the combined effects of two cytokines. In mice and monkeys, the combination of IL-3, IL-6 and IL-11 with G-CSF, GM-CSF, SCF or Tpo promoted hematopoietic recovery better than single factor, whereas patients with advanced tumors or high-grade sarcomas And solid tumors in children, the clinical effect of IL-3 + GM-CSF and IL-6 + G-CSF combination is not satisfactory, and the side effects are obvious. Therefore, in order to obtain a more satisfactory combination effect, it is also necessary to carefully study the factors such as the indication and dosage at the time of combination.