MHD stability of the Large Helical Device (LHD) plasmas produced with intense neutral beam injection is experimentally studied. When the steep pressure gradient near the edge is produced through L-H transition or linear density ramp experiment, interchange-like MHD modes whose rational surface is located very close to the last closed flux surface are strongly excited in a certain discharge condition and affect the plasma transport appreciably. In NBI-heated energetic ion loss, but also trigger the formation of internal and edge transport barriers.