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目的将异丙酚与小剂量阿片类药芬太尼联合应用于人工流产 ,从而减少其副作用。方法62例孕妇随机分成两组 :异丙酚组(D组) ,用3mg/kg 作为诱导 :芬太尼与异丙酚组(FD)先静脉注射0 1mg 芬太尼 ,接着静脉注射异丙酚1 26mg/kg,维持剂量两组相同均为异丙酚30mg/次 ,静脉注射直至能耐受手术。结果麻醉效果满意优等效果两组无差异(P>0 05) ;异丙酚用药量D组高于FD组差异有非常显著性(P<0 01) ;停用异丙酚至意识恢复时间两组无差异(P>0 05) ,收缩压与心率乘积(RPP)静脉注射异丙酚即刻两组无差异(P>0 05) ,而2min时 ,FD组与D组比较有非常显著性(P<0 01)。结论人工流产术中芬太尼与异丙酚联合用药优于单纯用异丙酚 ,还可节省费用 ,值得推广。
Objective To reduce the side effect of propofol in combination with low dose opioid fentanyl in induced abortion. Methods Sixty-two pregnant women were randomly divided into two groups: propofol group (D group), induced with 3 mg / kg of fentanyl and propofol (FD), followed by intravenous injection of 0.1 mg of fentanyl followed by intravenous injection of isopropyl Phenol 1 26mg / kg, maintenance dose of the same two groups were 30mg propofol / intravenous injection until can tolerate surgery. Results There was no significant difference between the two groups (P> 0.05). The dosage of propofol in group D was higher than that in group FD (P <0.01). The rate of propofol withdrawal to consciousness recovery time was two (P> 0.05). There was no difference between intravenous injection of propofol and systolic blood pressure (RPP) immediately (P> 0.05), but there was a significant difference between FD group and D group P <0 01). Conclusions The combination of fentanyl and propofol in induced abortion is better than that of propofol alone, which saves money and is worth popularizing.