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目的比较奥美拉唑与泮托拉唑治疗消化性溃疡的有效性及安全性。方法选取2012年4月—2015年4月东方医院收治的消化性溃疡患者52例,按照1:1比例分为对照组(n=26)和治疗组(n=26)。对照组予以奥美拉唑治疗,治疗组予以泮托拉唑治疗,比较两组患者临床疗效、不良反应发生率及症状消失时间和复发率。结果治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率、症状消失时间和复发率比较,差异无统计学意义(P>0.05)。结论奥美拉唑与泮托拉唑治疗消化性溃疡疗效相当,安全可靠,临床可根据患者实际情况酌情给药。
Objective To compare the efficacy and safety of omeprazole and pantoprazole in the treatment of peptic ulcer. Methods 52 patients with peptic ulcer admitted to Dongfang Hospital from April 2012 to April 2015 were divided into control group (n = 26) and treatment group (n = 26) according to the ratio of 1: 1. The control group was treated with omeprazole, and the treatment group was treated with pantoprazole. The clinical efficacy, the incidence of adverse reactions, the disappearance of symptoms and the relapse rate were compared between the two groups. Results The total effective rate of the treatment group was higher than that of the control group, with significant difference (P <0.05). There was no significant difference between the two groups in the incidence of adverse reactions, the disappearance of symptoms and the recurrence rate (P> 0.05). Conclusion Omeprazole and pantoprazole treatment of peptic ulcer effect is quite safe and reliable, according to the actual situation of patients with clinical discretion.