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观察了４８例心津失常者（室性３６例、房性１２例）服用盐酸莫雷西嗪的临床疗效及其与血药浓度的关系，以２４ｈ动态心电图监测及２次／ｄ，测心率、心律评价疗效。总有效率６２％，室性６９％，房性４２％。平均有效剂量为６００～８００ｍｇ／ｄ，平均起效时间为药后２～３ｈ，不良反应少而轻，因头晕、恶心中途停药２例，致心律失常４例，使原有阵发房颤加重。平均有效及无效血药浓度分别为２１２．９±１７８．１μｇ／Ｌ及２１７．４±２７１．０μｇ／Ｌ，６００～８００ｍｇ／ｄ时平均有效血药浓度分别为１７１．７±。１７５．１μｇ／Ｌ及２６４．２±１５１．７μｇ／Ｌ。研究结果示该药对室性、室上性心律失常有一定疗效，但也有致心律失常作用，血药浓度与疗效及剂量相关性差，故临床治疗应根据临床疗效及不良反应来调整剂量。
48 patients with ventricular dysfunction (ventricular in 36 cases, atrial in 12 cases) taking metoclopramide hydrochloride clinical efficacy and its relationship with plasma concentration, 24h dynamic electrocardiogram monitoring and 2 times / d, measured heart rate , Heart rate evaluation efficacy. The total effective rate of 62%, 69% of room, atrial 42%. The average effective dose of 600 ~ 800mg / d, the average onset time of 2 ~ 3h after the drug, adverse reactions less and light, due to dizziness, nausea and drug withdrawal in 2 cases, arrhythmia in 4 cases, the original paroxysmal atrial fibrillation Increase. The mean effective and ineffective plasma concentrations were 212.9 ± 178.1μg / L and 217.4 ± 271.0μg / L, respectively, and the mean effective plasma concentrations of 600-800mg / day were 171.7 ±. 175.1 μg / L and 264.2 ± 151.7 μg / L. The results show that the drug on ventricular and supraventricular arrhythmias have a certain effect, but also have induced arrhythmia, plasma concentration and efficacy and dose-related poor, so clinical treatment should be based on clinical efficacy and adverse reactions to adjust the dose.