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目的探讨高危型人乳头瘤病毒(HPV)检测在宫颈癌前病变早期筛查中的临床意义。方法选取2012年1月至2013年12月我院收治的宫颈癌前病变患者86例为观察组,同期选取我院门诊收治的慢性宫颈炎患者120例为对照组,检测两组患者宫颈组织中HPV阳性情况、相对含量及HPV阳性患者中HPV DNA不同亚型的构成情况。结果观察组患者的HPV阳性例数和相对含量均高于对照组;HPV阳性患者中,HPV亚型中DNA-16和DNA-18的构成比最高,分别为27.4%、28.1%;DNA-52、DNA-56、DNA-58构成比次之,分别为15.6%、13.3%、15.6%。且观察组患者HPV-DNA-16、18、52、56、68的阳性率均高于对照组。结论高危型HPV-DNA-16、18、52、56、68的含量在宫颈癌前病变中明显增多,是早期筛查的理想指标。
Objective To investigate the clinical significance of high risk human papillomavirus (HPV) detection in early screening of cervical precancerous lesions. Methods From January 2012 to December 2013, 86 cases of cervical precancerous lesions treated in our hospital were selected as the observation group. 120 cases of chronic cervicitis treated in our hospital were selected as the control group in the same period. HPV-positive, relative content and HPV-positive patients in different forms of HPV DNA subtypes. Results The HPV positive cases and relative contents in the observation group were higher than those in the control group. Among HPV-positive patients, the highest proportion of DNA-16 and DNA-18 in HPV-positive was 27.4% and 28.1% respectively. DNA-52 , DNA-56 and DNA-58 were 15.6%, 13.3% and 15.6% respectively. The positive rate of HPV-DNA-16,18,52,56,68 in the observation group was higher than that in the control group. Conclusion High-risk HPV-DNA-16,18,52,56,68 levels in cervical precancerous lesions increased significantly, is an ideal indicator of early screening.