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目的探讨冠状动脉粥样硬化性心脏病(简称冠心病,CHD)患者血液循环中一氧化氮(NO)和血管性假血友病因子(vWF)含量的变化。方法分别应用硝酸酶还原法和ELISA法测定38名正常人和39名CHD患者的血清NO、vWF因子及血脂的含量。结果CHD患者血清NO含量为(56.3±21.0)μmol?l,显著低于正常对照组(79.7±21.1)μmol?l(t=4.41,P<0.001);CHD患者的血浆vWF因子含量(182.0±21.0)%显著高于正常对照组(142.0±24.0)%(t=7.34,P<0.001)。结论CHD的发生可能与NO的减少和vWF的增加有关。
Objective To investigate the changes of blood nitric oxide (NO) and von Willebrand factor (vWF) in patients with coronary atherosclerotic heart disease (CHD). Methods The levels of serum NO, vWF and serum lipids in 38 normal subjects and 39 CHD patients were determined by nitratase reduction and ELISA respectively. Results The serum level of vWF in CHD patients was (56.3 ± 21.0) μmol? L, significantly lower than that in the normal controls (79.7 ± 21.1) μmol? L (t = 4.41, 21.0%) was significantly higher than that of the control group (142.0 ± 24.0)% (t = 7.34, P <0.001). Conclusions The occurrence of CHD may be related to the decrease of NO and the increase of vWF.