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本文用~3H-TdR、~(35)S-Na_2SO_4双核素标记法,观察了人单核细胞IL-1对大鼠肾小球上皮细胞(GEC)增殖和细胞层~(35)SO~(2-)_4掺入量的影响。结果示:IL-1促进GEC增值作用明显(p<0.05),对细胞层~(35)SO~(2-)_4掺入量有显著促进作用(P<0.01)。提示IL-1在某些伴上皮细胞增殖的肾小球疾病中起重要作用。
The effect of IL-1 on the proliferation and the expression of ~ (35) SO ~ (-) in rat glomerular epithelial cells (GECs) was observed by ~ 3H-TdR and ~ (35) S-Na_2SO_4 dual- 2 -) _ 4 Effect of incorporation. The results showed that IL-1 promoted the proliferation of GEC significantly (p <0.05), and promoted the incorporation of SO 2- (2) 4 in the cytoplasm significantly (P <0.01). This suggests that IL-1 plays an important role in glomerular diseases associated with epithelial cell proliferation.