目的:探讨脑卒中老年患者出院带药处方中的潜在不适当用药（PIM）发生情况及其影响因素。方法:收集2016年7月至2017年12月从汕头大学医学院第一附属医院神经内科（共2个病区，其中1个有临床药师参与患者出院带药管理）出院的脑卒中老年患者（≥65岁）病历资料进行回顾性分析。记录患者的基本信息（性别、年龄、住院时间、病区等）、出院诊断和出院带药处方，依据美国老年医学会（AGS）的2019年版Beers标准对患者出院处方中的PIM进行评价，并将纳入分析的患者按性别、年龄（65~74、75~84、≥85岁）、罹患疾病种数（1~5、6~10、≥11种）、查尔森共病指数（1、2、≥3分）、住院时间（≤15、16~20、≥21 d）、处方药品种数（1~4、5~9、≥10种）以及所在病区有无临床药师参与工作等临床特征分组，比较PIM的发生情况。采用多因素logistic回归方法分析PIM的影响因素。结果:纳入分析的患者共435例，男性230例，女性205例；年龄65~92岁；出院带药处方药品数2~16种，中位数为6种；有药师参与病区患者200例，无药师参与病区患者235例。435例患者的435份处方中有179份处方存在PIM，PIM发生率为41.15%。179份处方共存在PIM 280例次。多因素logistic回归分析结果显示，处方药品数≥5是PIM发生的独立危险因素[比值比（n OR）=2.617，95%置信区间（n CI）：1.689~4.054，n P<0.001]，药师参与出院带药管理是PIM的防护因素（n OR=0.673，95n %CI：0.457~0.990，n P=0.045）。n 结论:我院脑卒中老年患者出院带药处方的PIM发生率为41.15%。PIM的发生与处方药品种数有关，药师参与出院带药管理有助于减少PIM的发生。“,”Objective:To explore the occurrence of potentially inappropriate medication (PIM) and its influencing factors in discharge prescriptions in elderly patients with stroke.Methods:The medical record data of elderly patients (≥65 years) with stroke, who were discharged from the Department of Neurology in the First Affiliated Hospital of Shantou University Medical College between July 2016 and December 2017, were collected and retrospectively analyzed. There were 2 wards in the Department of Neurology in total, 1 of which had clinical pharmacists to participate in medication management of the discharged patients. The patients′ basic information (gender, age, length of hospital stay, ward, and etc.), discharge diagnosis, and discharge prescriptions were collected. PIM in discharge prescriptions in the patients was evaluated according to the 2019 American Geriatrics Society Beers criteria. The patients were grouped according to their gender, age (65-74, 75-84, ≥85 years), number of diseases (1-5, 6-10, ≥11), Charlson comorbidity index (1, 2, ≥3), length of hospital stay (<15, 16-20, ≥21 d), number of prescribed drugs (1-4, 5-9, ≥10), and with or without clinical pharmacists involving in medication management in the ward, and the occurrence of PIM was compared. The influencing factors of PIM were analyzed using multivariate logistic regression method.Results:A total of 435 patients were included in the analysis. Of them, 230 were males and 205 were females, with ages from 65 to 92 years; the number of drugs in discharge prescriptions ranged from 2 to 16, with a median number of 6; 200 patients were in ward with pharmacists participating in the management and 235 patients in ward without pharmacists participating in the management. One hundred and seventy-nine prescriptions were found with PIM in 435 patients and the incidence of PIM was 41.15%. A total of 280 times of PIM were found in 179 prescriptions. Multivariate logistic regression analysis showed that the number of prescribed drugs (≥5) was an independent risk factor for the occurrence of PIM [odds ratio (n OR)=2.617, 95n % confidence interval (n CI): 1.689-4.054, n P<0.001], and the participation of pharmacists in discharge medication management was a protective factor for PIM (n OR=0.673, 95n %CI: 0.457-0.990, n P=0.045).n Conclusions:The incidence of PIM in discharge prescriptions in elderly patients with stroke was 41.15%. The occurrence of PIM was related to the number of prescribed drugs. Pharmacists′ participation in the management of discharge medications helps to reduce the occurrence of PIM.