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目的观察法舒地尔对急性脑梗死患者血浆一氧化氮和内皮素-1的影响,探讨该药的作用及机制。方法将69例发病48h内的急性脑梗死患者随机分为治疗组35例,对照组34例,治疗组除基础治疗外加用法舒地尔60mg/d,治疗前及治疗15d后分别进行神经功能缺损评分,同时测定血浆一氧化氮(NO)及血管内皮素-1(ET-1)水平。结果治疗后治疗组及对照组血浆NO水平明显升高(P<0.05),神经功能缺损评分明显下降(P<0.05)。治疗组血浆NO水平较对照组明显升高(P<0.05),ET-1水平及神经功能缺损评分均较对照组明显下降(P<0.05)。结论法舒地尔能有效的改善血管内皮功能,保护神经细胞,降低神经功能缺损程度。
Objective To observe the effects of fasudil on plasma nitric oxide and endothelin-1 in patients with acute cerebral infarction and to explore its mechanism and mechanism. Methods Sixty-nine patients with acute cerebral infarction within 48 hours after onset were randomly divided into treatment group (n = 35) and control group (n = 34). In addition to basic treatment, fasudil 60 mg / d was given to the treatment group, and neurological deficits The plasma levels of nitric oxide (NO) and endothelin-1 (ET-1) were measured at the same time. Results After treatment, the levels of plasma NO in the treatment group and the control group were significantly increased (P <0.05), and the neurological deficit scores were significantly decreased (P <0.05). The level of plasma NO in the treatment group was significantly higher than that in the control group (P <0.05), and the ET-1 level and neurological deficit score were significantly lower than those in the control group (P <0.05). Conclusion fasudil can effectively improve endothelial function, protect nerve cells and reduce the degree of neurological deficits.