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目的 研究胃癌病人血清胃泌素 (Gs)含量升高的原因。方法 应用放免法测定胃癌病人血清Gs含量 ,并分析其与胃癌发生部位、临床病理分期、预后的关系以及手术前后血清Gs的变化。结果 胃底贲门癌病人血清Gs值明显升高 ,而胃窦癌、胃体癌血清Gs值与正常对照组接近 ;随着胃癌临床病理分期的进展 ,血清Gs含量逐渐升高 ;胃癌术后 2周血清Gs含量虽明显下降 ,但术后 3个月恢复到与术前水平相当 ;对 41例不能手术切除的胃癌病人进行随访 ,发现生存期超过 1年者血清Gs含量与生存期未超过 1年者接近。结论 胃癌病人血清Gs升高是一种继发性改变 ,不能作为一种肿瘤标志物 ,也不能作为一个预后因素
Objective To study the causes of elevated serum gastrin (Gs) in patients with gastric cancer. Methods The serum Gs levels in patients with gastric cancer were measured by radioimmunoassay, and their relationship with the site of gastric cancer, clinical pathological stage, prognosis, and changes of serum Gs before and after surgery were analyzed. Results The serum Gs value of gastric cardia cancer patients was significantly increased, while the serum Gs values of gastric cancer and gastric cancer were similar to those of the normal control group. With the progress of the clinical pathological stage of gastric cancer, the serum Gs level was gradually increased; Although serum Gs levels decreased significantly during the week, they recovered to the same level as preoperative levels at 3 months after operation. Follow-up was performed on 41 patients with gastric cancer who were not surgically resected. The serum Gs level and survival period did not exceed 1 in patients who survived for more than 1 year. The year is close. Conclusion The increase of serum Gs in gastric cancer patients is a secondary change and cannot be used as a tumor marker or as a prognostic factor.