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氧化应激是一种活性氧代谢引起的分子失调,是心血管疾病的病理过程的关键机制之一。氧化应激的关键机制是氧化激酶功能的异常,特别是还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶的异常。因此,抑制特定的NADPH氧化酶亚型已经成为治疗心血管疾病的重要策略。目前临床上应用肾素-血管紧张素-醛固酮系统阻断剂、他汀类药物、钙通道阻断剂、胆碱能激动剂/阻断剂、大麻素受体阻断剂和蛋白激酶C抑制剂均可抑制NADPH氧化酶的激活和/或表达。这些药物可能对治疗心血管疾病发挥重要作用。
Oxidative stress is a molecular disorder caused by reactive oxygen species metabolism and is one of the key mechanisms of the pathological process of cardiovascular diseases. The key mechanism of oxidative stress is the abnormality of oxidative kinase function, especially the abnormality of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Therefore, the inhibition of specific NADPH oxidase subtypes has become an important strategy for the treatment of cardiovascular diseases. At present, the clinical application of renin-angiotensin-aldosterone system blockers, statins, calcium channel blockers, cholinergic agonists / blockers, cannabinoid receptor blockers and protein kinase C inhibitors Can inhibit the activation and / or the expression of NADPH oxidase. These drugs may play an important role in the treatment of cardiovascular disease.