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有认为中枢神经系统(CNS)损伤中兴奋性氨基酸与抑制性氨基酸的失衡,在兴奋毒性激发中起一定作用,并与多种因素参与造成脑损伤。为了进一步探讨新生儿缺氧缺血性脑病与兴奋性氨基酸及抑制性氨基酸的关系,我科自1997年1月至1998年1月,对新生儿缺氧缺血性脑病(HIE)患儿的脑脊液(CSF)中谷氨酸(GLU),γ氨基丁酸(GABA)含量及酶活性进行观察,并作CT扫描,现报道如下。1 对象与方法 1.1 对象 病例组:按1996年杭州会议诊断HIE标准,足月儿20例,男14例,女6例,平均日龄2.5天(4小时至3天),其
It is thought that the imbalance between excitatory amino acids and inhibitory amino acids in central nervous system (CNS) damage plays a role in the excitotoxic stimuli and is involved in many kinds of brain damage. In order to further explore the relationship between neonatal hypoxic ischemic encephalopathy and excitatory amino acids and inhibitory amino acids, our department from January 1997 to January 1998, neonatal hypoxic-ischemic encephalopathy (HIE) in children Cerebrospinal fluid (CSF) glutamic acid (GLU), γ-aminobutyric acid (GABA) content and enzyme activity were observed and CT scan, are reported below. 1 Subjects and methods 1.1 Object cases group: According to the HIE standard of Hangzhou meeting in 1996, 20 full-term infants, 14 males and 6 females, average age 2.5 days (4 hours to 3 days), the