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目的研究柴胡疏肝散对急性应激胃溃疡大鼠血浆、胃、蓝斑中胃泌素及生长抑素含量的干预作用。方法将32只大鼠随机分为正常对照组、胃溃疡模型组、柴胡疏肝散组、雷尼替丁组,采用不可预知性刺激造成大鼠急性胃溃疡模型,观察各组大鼠血浆、胃、蓝斑中胃泌素及生长抑素含量的变化。结果与模型组相比,柴胡疏肝散不仅能明显降低血浆、胃中胃泌素含量,而且能降低胃组织中的生长抑素含量,差异均有统计学意义(P<0.05),血浆中生长抑素未见明显降低(P>0.05),蓝斑中两者差异均无统计学意义(P>0.05),但雷尼替丁能显著降低蓝斑中胃泌素含量、血浆中生长抑素含量,差异均有统计学意义(均P<0.05),而对蓝斑中生长抑素含量则无影响。结论柴胡疏肝散改善外周或中枢胃泌素及生长抑素含量可能是治疗应激性胃溃疡的作用机制之一。
Objective To investigate the effect of Chaihu Shugan San on gastrin and somatostatin in plasma, stomach and locus coeruleus in rats with acute gastric ulcer. Methods Thirty-two rats were randomly divided into normal control group, gastric ulcer model group, Chaihu Shugan Powder group and ranitidine group. Rats with acute gastric ulcer were induced by unpredictable stimulation. , Gastrocnemius and somatostatin in stomach and locus coeruleus. Results Compared with the model group, Chaihu Shugan San not only can obviously reduce the content of gastrin in plasma and stomach, but also reduce the content of somatostatin in gastric tissue (P <0.05) (P> 0.05). There was no significant difference between the two groups in locus coeruleus (P> 0.05), but ranitidine could significantly reduce the content of gastrin in plasma and the plasma growth The content of somatostatin and the difference were all statistically significant (all P <0.05), but had no effect on the content of somatostatin in locus coeruleus. Conclusion Chaihu Shugan San improve peripheral or central gastrin and somatostatin content may be one of the mechanisms of treatment of stress ulcer.