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采用国产药用辅料,运用均匀设计方法对阿司匹林分散片处方进行筛选,给出三种崩解剂或溶胀性辅料占处方的比例分别为5%,7%,5%.经过对优选处方的实验表明:崩解时间小于3min,分散均匀性试验能通过710μm筛网,均达到英国药典(1993年版)要求;体外溶出试验表明:T50=1.161min,Td=2.109min,与阿司匹林普通片溶出参数比较有显著差异,分散片溶出速度快,30min内几乎全部溶出.
The domestic pharmaceutical excipients were used to screen the prescriptions of aspirin dispersible tablets by uniform design method. The proportions of the three disintegrants or swelling excipients were 5%, 7% and 5% respectively. The results showed that: the disintegration time was less than 3min, the dispersion uniformity test could pass through the 710μm sieve, which met the requirements of British Pharmacopoeia (1993 edition); in vitro dissolution test showed that: T50 = 1.161min, Td = 2.109min , And aspirin common tablets dissolution parameters were significantly different, dispersible tablets dissolution speed, almost all within 30min dissolution.