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目的 探讨慢性胃炎患者实施幽门螺杆菌根除性治疗的价值?方法 将我院2018年3月至2019年8月慢性胃炎患者100例，随机分组，三联幽门螺杆菌根除性治疗组就诊患者采取三联幽门螺杆菌根除性治疗，四联幽门螺杆菌根除性治疗组对本次就诊患者采取四联幽门螺杆菌根除性治疗?比较两组慢性胃炎疗效;幽门螺杆菌根除时间?腹部胀痛消失时间?餐后泛酸消失时间?上腹疼痛消失的时间;治疗前后患者临床症状积分?胃镜症状评分?高敏C反应蛋白监测值?白细胞介素-6以及肿瘤坏死因子α;不良反应?结果 四联幽门螺杆菌根除性治疗组慢性胃炎疗效“,”Objective To explore the value of Helicobacter pylori eradication in the treatment of chronic gastritis. Methods One hundred patients with chronic gastritis in our hospital from March 2018 to August 2019 were randomly divided into three groups. Patients in the triple Helicobacter pylori eradication treatment group received triple Helicobacter pylori eradication treatment，while patients in the quadruple Helicobacter pylori eradication treatment group received quadruple Helicobacter pylori eradication treatment. The curative effect of chronic gastritis，eradication time of Helicobacter pylori，disappearance time of abdominal distention and pain，disappearance time of pantothenic acid and upper abdominal pain，clinical symptom score，gastroscope symptom score，monitoring value of high-sensitivity C-reactive protein，interleukin-6 and tumor necrosis factor α before and after treatment were compared. Results The curative effect of chronic gastritis in the treatment group was higher than that in the treatment group (P<0.05). The eradication time，abdominal pain，pantothenic acid and epigastric pain in the quadruple Helicobacter pylori eradication group were shorter than those in the triple Helicobacter pylori eradication group (P<0.05). The clinical symptom score，gastroscope symptom score，high-sensitivity C-reactive protein monitoring value，interleukin-6 and tumor necrosis factor α in the quadruple Helicobacter pylori eradication treatment group were better than those in the triple Helicobacter pylori eradication treatment group (P<0.05). Among the adverse reactions of the two groups，1 case of abdominal discomfort and 1 case of diarrhea were found in the treatment group. There were 4 cases of dry mouth，3 cases of diarrhea and 2 cases of epigastric discomfort in the triple Helicobacter pylori eradication treatment group (P<0.05). Conclusion The curative effect of quadruple Helicobacter pylori eradication on chronic gastritis is good. Compared with triple Helicobacter pylori eradication treatment group，the patients can improve their condition faster and better，eradicate Helicobacter pylori，shorten the treatment time and reduce the adverse reactions.