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本文报道有机锗化合物对正常小自鼠和 S_(180)肉瘤小白鼠肝脏微粒体的细胞色素 P-450、尿苷二磷酸葡萄糖醛酸基转移酶(简称“UDP-GT”)及蛋白质含量的影响。将有机锗化合物按0.2mg/g 体重剂量给正常小白鼠灌胃6天或12天时,肝微粒体的细胞色素 P-450和蛋白质的含量减少,胚胎型 UDP-GT 即o-GT 的活力增高。S_(180)肉瘤小白鼠与正常小白鼠比较,其肝微粒体的细胞色素 P—450的含量减少,而蛋白质含量增高,但 UDP—GT 活力无著变。S_(180)肉瘤小白鼠经有机锗化合物治疗,肿块明显缩小后,肝微粒体的细胞色素 P—450和蛋白质含量恢复到正常水平。我们认为有机锗化合物的抗肿瘤效应可能是与降低细胞色素 P—450的含量,增进 UDP—GT 的结合解毒作用有关系.
This article reports on the content of cytochrome P-450, uridine diphosphate glucuronyltransferase (abbreviated as “UDP-GT”) and protein in the liver microsomes of normal small mice and S_(180) sarcoma mice. influences. When organic germanium compounds were administered to normal mice at a dose of 0.2 mg/g body weight for 6 days or 12 days, the contents of cytochrome P-450 and protein in liver microsomes decreased, and the activity of embryonic UDP-GT (o-GT) increased. . Compared with normal white mice, S_(180) sarcoma mice showed reduced levels of cytochrome P-450 in liver microsomes and increased protein content but no change in UDP-GT activity. S_(180) sarcoma mice were treated with organogermanium compounds. After the tumors were significantly reduced, the cytochrome P-450 and protein content of liver microsomes returned to normal levels. We believe that the anti-tumor effect of organic quinone compounds may be related to the decrease of cytochrome P-450 content and increase the combined detoxification of UDP-GT.