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目的:探讨骨桥蛋白(OPN)和肌节同源盒基因同系物2(Msx2)在鼻内翻性乳头状瘤(SNIP)组织中的表达和意义,及两因子在SNIP恶变发生、发展过程中的关系。方法:采用免疫组织化学SP法检测OPN和Msx2在32例SNIP、30例鼻息肉(INP)和30例恶变SNIP蜡块组织中的表达情况,其中SNIP组又根据病理形态分为轻度不典型增生组、中度不典型增生组和重度不典型增生组。所有数据均采用SPSS13.0软件包进行统计学分析。结果:OPN和Msx2在恶变SNIP组中的阳性表达率均为100%(30/30),均显著高于SNIP组和INP组中的阳性表达率,且两两比较差异均有统计学意义(P<0.05)。OPN和Msx2在SNIP的三个病理形态分组间的阳性表达比较:轻度不典型增生组与重度不典型增生组比较差异具有统计学意义(P<0.05),而轻度不典型增生组与中度不典型增生组比较、中度不典型增生组与重度不典型增生组比较差异均无统计学意义(P>0.05)。OPN和Msx2在SNIP中的表达呈正相关(P<0.01)。结论:OPN和Msx2在SNIP恶变的发生、发展过程中起重要作用,有可能成为SNIP基因治疗的靶点。
Objective: To investigate the expression and significance of osteopontin (OPN) and sarcolemmal homologue 2 (Msx2) in nasal inverted papilloma (SNIP) tissues and to explore the role of two factors in the pathogenesis and progression of SNIP In the relationship. Methods: Immunohistochemical SP method was used to detect the expression of OPN and Msx2 in 32 cases of SNIP, 30 cases of nasal polyps (INP) and 30 cases of malignant SNIP. The SNIP group was divided into mild atypical Hyperplasia group, moderate dysplasia group and severe dysplasia group. All data were SPSS13.0 software package for statistical analysis. Results: The positive rates of OPN and Msx2 in malignant SNIP group were all 100% (30/30), which were significantly higher than those in SNIP group and INP group (P <0.05) P <0.05). The positive expression of OPN and Msx2 in three SNIP pathological groups: the difference between mild dysplasia group and severe dysplasia group was statistically significant (P <0.05), while mild dysplasia group and moderate dysplasia group Atypical hyperplasia group, there was no significant difference between moderate dysplasia group and severe dysplasia group (P> 0.05). The positive expression of OPN and Msx2 in SNIP (P <0.01). Conclusion: OPN and Msx2 play an important role in the occurrence and development of SNIP malignant transformation, which may be the target of SNIP gene therapy.