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目的探讨2型糖尿病患者血栓调节蛋白(thrombomodulin,TM)水平与合并冠心病的关系。方法选择2007年1月至2008年3月在本院住院的97例糖尿病患者,把合并冠心病患者分为稳定型心绞痛组、不稳定型心绞痛组和心肌梗死组。应用酶联免疫吸附测定(ELISA)检测其血浆TM水平,并对血浆TM与冠状动脉病变作相关分析。结果不稳定型心绞痛组血浆TM水平高于稳定型心绞痛组;心肌梗死组明显高于不稳定型心绞痛组。结论2型糖尿病合并冠心病患者,随着冠状动脉粥样硬化病变程度加重,血浆TM水平可能相应升高。监测2型糖尿病患者血浆TM水平,对预测其冠状动脉粥样硬化病的严重程度可能有一定意义。
Objective To investigate the relationship between thrombomodulin (TM) and coronary heart disease in type 2 diabetic patients. Methods From January 2007 to March 2008 in our hospital 97 cases of diabetic patients with coronary heart disease were divided into stable angina pectoris group, unstable angina pectoris group and myocardial infarction group. The level of plasma TM was measured by enzyme-linked immunosorbent assay (ELISA), and the correlation between plasma TM and coronary artery disease was analyzed. Results The level of plasma TM in unstable angina group was higher than that in stable angina group. The myocardial infarction group was significantly higher than that in unstable angina group. Conclusions Patients with type 2 diabetes mellitus and coronary heart disease may have correspondingly elevated plasma TM levels with the severity of coronary atherosclerosis. Monitoring plasma TM levels in patients with type 2 diabetes may have some implications for predicting the severity of coronary atherosclerosis.