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目的中草药对胃癌有抑制作用，但其作用的有关机制尚不清楚，通过诱发大鼠胃癌模型，研究复方参七汤对胃癌的抑制作用．方法采用Ｎ甲基Ｎ＇硝基Ｎ亚硝基胍（ＭＮＮＧ）１００ｍｇ／Ｌ连续喂养Ｗｉｓｔａｒ大鼠９ｍｏ，制成胃癌模型，实验大鼠在喂养ＭＮＮＧ的同时，连续喂给中药复方参七汤１８ｍＬ／ｋｇ．观察实验组和对照组胃癌的发生率．结果实验组胃癌发生率为６９％（３／４３），对照组胃癌发生率为５８９％（２３／３９）．两组比较有显著差异（Ｐ＜００１）．结论复方参七汤能显著降低ＭＮＮＧ诱发的大鼠胃癌发生率，对胃癌有明显的抑制和预防作用．
The purpose of Chinese herbal medicine has an inhibitory effect on gastric cancer, but the mechanism of its role is not yet clear, through the induction of rat gastric cancer model, research compound Shenqi Decoction inhibition of gastric cancer. METHODS: Wistar rats were continuously fed with N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) at a dose of 100 mg/L for 9 months to establish a gastric cancer model. Rats were fed with MNNG and continuously given Chinese medicine. Compound Shenqi Tang 18mL/kg. Observed the incidence of gastric cancer in the experimental group and the control group. Results The incidence of gastric cancer was 6.9% (3/43) in the experimental group, and 58.9% (23/39) in the control group. There was a significant difference between the two groups (P<001). Conclusion Compound Shenqi Decoction can significantly reduce the incidence of gastric cancer induced by MNNG in rats, and has obvious inhibition and prevention effects on gastric cancer.