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目的:探讨人胃腺癌患者组织中p38MAPK表达情况与多药耐药因子P170、GST-π以及临床病理情况、相同化学治疗后患者生存期之间的关系及意义。方法:随机选取大连医科大学附属第一医院2007年至2012年胃癌根治术后且病理类型为胃腺癌,经方案大体一致的系统化学治疗、随诊资料完整的73例患者。应用免疫组化方法对病理标本进行检测,收集p38MAPK以及已知多药耐药因子P170和GST-π的表达情况,结合患者的年龄、性别、肿瘤位置、肿瘤分化程度、肿瘤分期等病理情况和生存期等预后资料,总结后应用SPSS软件对数据进行统计学分析。结果:入选人胃腺癌病例中p38MAPK总阳性表达率为72.6%,但与患者年龄、性别、肿瘤位置、肿瘤分化程度、肿瘤分期无相关性(P>0.05);p38MAPK阳性表达率与P170及GST-π率阳性表达率均呈负相关(P<0.05);经过相同化学治疗后p38MAPK阳性表达患者中位生存时间为22.9个月,比p38MAPK阴性表达的14.7个月明显延长(P<0.05),同时p38MAPK阳性表达率与肿瘤化学治疗预后生存期存在相关性(P<0.05)。结论:p38MAPK阳性表达率与胃腺癌患者的年龄、性别、肿瘤位置、肿瘤分化程度、肿瘤分期无相关性;但p38MAPK阳性表达率与已知多药耐药因子P170和GST-π阳性表达率呈负相关,p38MAPK阳性高表达是胃腺癌化学治疗预后生存期的有利因素,可能降低化学治疗药物的多药耐药性。
Objective: To investigate the relationship between the expression of p38MAPK in human gastric adenocarcinoma tissues and the multidrug resistance factor P170 and GST-π as well as their clinical and pathological features and the survival of patients after the same chemotherapy. Methods: A total of 73 patients with complete follow-up data were randomly selected from the First Affiliated Hospital of Dalian Medical University from 2007 to 2012 after radical gastrectomy and the pathological type was gastric adenocarcinoma. Immunohistochemistry was used to detect the pathological specimens. The expression of p38MAPK and the known multidrug resistance factors P170 and GST-π were collected. Combined with the patient’s age, gender, tumor location, tumor differentiation, tumor stage and other pathological conditions and survival Period and other prognostic data, summed up the application of SPSS software for statistical analysis of the data. Results: The positive rate of p38MAPK in gastric adenocarcinoma was 72.6%, but there was no correlation with age, gender, tumor location, tumor differentiation and tumor stage (P> 0.05). The positive rate of p38MAPK was significantly correlated with P170 and GST (P <0.05). The median survival time of patients with p38MAPK positive expression after the same chemotherapy was 22.9 months (P <0.05), which was significantly longer than that of p38MAPK negative expression (14.7 months) At the same time, the positive rate of p38MAPK correlated with the prognosis of tumor chemotherapy (P <0.05). Conclusion: There is no correlation between the positive rate of p38MAPK and the age, gender, tumor location, tumor differentiation and tumor stage in patients with gastric adenocarcinoma. However, the positive rate of p38MAPK is negatively correlated with the positive rate of known multidrug resistance factor P170 and GST-π Related, p38MAPK positive high expression of gastric adenocarcinoma chemotherapy prognostic survival of favorable factors, may reduce the multidrug resistance of chemotherapeutic drugs.