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目的:探讨糖尿病足大截肢患者的临床特征，并分析相关危险因素。方法:回顾性分析2011年1月至2018年6月北京东直门医院周围血管科住院的2 210例糖尿病足溃疡患者的临床资料。根据是否有大截肢，将本组患者分为两组，分别为大截肢组（93例）和对照组（2 117例）。采用单因素分析、多因素logistic回归分析糖尿病足大截肢的危险因素。结果:多因素logistic回归分析显示透析（n OR=2.78, 95%n CI：1.10~7.51，n P=0.027）、静息痛（n OR=27.89, 95%n CI：6.89~112.83，n P<0.001）、足跟部溃疡（n OR=9.07, 95%n CI：1.19~11.13，n P=0.016）、骨质破坏（n OR=2.61, 95%n CI：1.07~6.32，n P=0.033）、ABI低（n OR=13.93, 95%n CI：3.56~54.54，n P<0.001）、IDSA分级中重度感染（n OR=7.12, 95%n CI：1.44~29.37，n P=0.035）是糖尿病足大截肢的独立危险因素。n 结论:进行透析、静息痛、足跟部溃疡、骨质破坏、ABI低以及IDSA分级为3~4级是糖尿病足患者大截肢的独立危险因素。早期识别独立危险因素并积极干预，是预防大截肢发生的关键。“,”Objective:To investigate the clinical characteristics and risk factors for major amputation in patients with diabetic foot.Methods:A retrospective study was performed on the clinical data of 2 210 patients with diabetic foot ulcer at the Department of Peripheral Vascular of Beijing Dongzhimen Hospital from January 2011 to June 2018. The patients were divided into two groups according to whether they received major amputation: the major amputation group (n n=93) and the control group (n n=2 117). Risk factors of major amputation in patients with diabetic foot were analyzed through multifactorial logistic regression combined with single factor analysis.n Results:Logistic regression analysis showed that dialysis (n OR=2.78, 95%n CI:1.10-7.51, n P=0.027), rest pain (n OR=27.89, 95%n CI: 6.89-112.83, n P<0.001), heel ulcer (n OR=9.07, 95%n CI:1.19-11.13, n P=0.016), bone destruction (n OR=2.61, 95%n CI: 1.07-6.32, n P=0.033), low ABI (n OR=13.93, 95%n CI:3.56-54.54, n P<0.001) and moderate to severe infection under IDSA classification (n OR=7.12, 95%n CI:1.44-29.37, n P=0.035) were the independent risk factors of major amputation in patients with diabetic foot.n Conclusion:Dialysis, rest pain, heel ulcer, bone destruction, low ABI and IDSA grade 3 to 4 are the independent risk factors of major amputation in patients with diabetic foot. Early identification of independent risk factors combined with aggressive intervention is the key to preventing major amputation