建立了利用高效液相色谱-电喷雾离子阱质谱(HPLC-ESI-IT-MS/MS)测定近岸海水中多种常见全氟化合物(PFCs)的分析方法.采用固相萃取法(SPE)对海水中的PFCs净化富集,用HPLC-ESI-IT-MS/MS多反应离子监测(MRM)模式对各组分(全氟己烷磺酸、全氟辛烷磺酸、全氟辛烷磺酰胺、全氟己酸、全氟庚酸、全氟辛酸、全氟壬酸、全氟癸酸、全氟十一酸、全氟十二酸)进行测定.在最佳实验条件下,采用基质匹配标准曲线法定量,以消除海水基质的影响,8种目标化合物的检出限介于0.50—1.00 ng·L-1,9种PFCs的回收率在71.0%—130.2%之间,能满足近岸海水中多种PFCs检测的要求.青岛沿岸表层海水样品测定结果显示,全部采样站点的海水样品中均检测到≥4种PFCs,说明青岛沿岸海水中已有一定程度的PFCs污染. A method was developed for the determination of several common perfluorinated compounds (PFCs) in coastal seawater using high performance liquid chromatography-electrospray ion trap mass spectrometry (HPLC-ESI-MS-MS / MS) The PFCs in seawater were purified and enriched. The components (perfluorohexanesulfonic acid, perfluorooctane sulfonate, perfluorooctane sulfonate, perfluorooctane sulfonate, perfluorooctane sulfonate, perfluorooctane sulfonate, Sulfonamide, perfluorohexanoic acid, perfluoroheptanoic acid, perfluorooctanoic acid, perfluorononanoic acid, perfluorodecanoic acid, perfluoroundecanoic acid, perfluorododecanoic acid) under the best experimental conditions, using matrix matching The calibration curves were quantified to eliminate the influence of seawater matrix. The detection limits of eight target compounds ranged from 0.50-1.00 ng · L-1, and the recoveries of one or nine PFCs ranged from 71.0% -130.2% The requirements of various PFCs detection in seawater The determination results of surface seawater samples from the coastal areas of Qingdao showed that ≥4 PFCs were detected in the seawater samples of all sampling sites, indicating that there was a certain degree of PFCs pollution in the coastal waters of Qingdao.