Background Advanced age independently predicts early and late mortality and major adverse cardiac events (MACE)after percutaneous coronary intervention (PCI).Randomized clinical trials indicate that sirolimus-eluting stent (SES)implantation reduces target lesion revascularization (TLR),but there are limited data on the impact of age on outcomesfollowing SES implantation in patients with coronary artery disease (CAD) in real-world practice.Methods A total of 333 CAD patients with 453 lesions were enrolled in this study.Subjects were divided into two groupsaccording to age:a young group (<65 years old,244 patients with 369 lesions) and elderly group (≥65 years old,89patients with 113 lesions).Clinical follow-up and quantitative coronary angiography (QCA) were performed seven monthsafter PCI.Results Baseline clinical,demographic,angiographic,and procedural chararcteristics were similar in both groups,except that there were more female patients in the elderly group (21.3% vs 9.8%,P=0.006).Primary success rate wassimilar in both groups (96.5% in young group vs 95.7% in elderly group,P>0.05).During angiographic follow-up at 7months,binary in-stent restenosis and in-segment restenosis rates were not significantly different between the twogroups (4.7% vs 1.8%;9.7% vs 8.8%,P>0.05 respectively).Both sub-acute and late thrombosis rates were similar in thetwo groups (0.3% vs 0.9% and 1.2% vs 0.9%,P>0.05 respectively,).TLR was not significantly different between the twogroups (6.5% vs 3.5%;P=0.246).The rates of bleeding,stroke,angina rehospitalization during the follow-up period werealso similar in both groups (P>0.05 respectively).Conclusion Despite a high-risk clinical profile,coronary SES implantation can be safely and effectively performed inelderly patients with a similar procedural success rate,a low complication rate,and excellent 7-month outcomes. Background Advanced age independently predicts early and late mortality and major adverse cardiac events (MACE) after percutaneous coronary intervention (PCI). Randomized clinical trials indicate that sirolimus-eluting stent (SES) implantation reduces target lesion revascularization (TLR), but there are limited data on the impact of age on outcomesfollowing SES implantation in patients with coronary artery disease (CAD) in real-world practice. Methods A total of 333 CAD patients with 453 lesions were enrolled in this study. Subjects were divided into two groupsaccording to age: A young group (<65 years old, 244 patients with 369 lesions) and elderly group (≥65 years old, 89 patients with 113 lesions). Clinical follow-up and quantitative coronary angiography (QCA) were performed seven months after PCI. Results Baseline clinical , demographic, angiographic, and procedural chararcteristics were similar in both groups, except that there were more female patients in the elderly group (21.3% vs 9.8%, P = 0.006 ). Primary success rate wassimilar in both groups (96.5% in young group vs 95.7% in elderly group, P> 0.05) .During angiographic follow-up at 7months, binary in-stent restenosis and in-segment restenosis rates were not significant different between the twogroups (4.7% vs 1.8%, P> 0.05 respectively) .Both sub-acute and late thrombosis rates were similar in thetwo groups (0.3% vs 0.9% and 1.2% vs 0.9%, P> The rates of bleeding, stroke, angina rehospitalization during the follow-up period were also similar in both groups (P> 0.05 respectively). TLR was not significantly different between the twogroups (6.5% vs 3.5%; P = 0.246) ). Conclusions Despite a high-risk clinical profile, coronary SES implantation can be safely and effectively performed inelderly patients with a similar procedural success rate, a low complication rate, and excellent 7-month outcomes.