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绒毛膜羊膜炎多继发于未足月胎膜早破,与早产关系密切。因为早产是3/4以上新生儿死亡的直接原因,故应高度警惕绒毛膜羊膜炎的发生,尤其是亚临床绒毛膜羊膜炎易被忽略。大量文献分别研究了传统生物指标包括红细胞沉降率、白细胞计数、C-反应蛋白,及近代分子生物指标包括基质金属蛋白酶、白细胞介素和肿瘤坏死因子等对绒毛膜羊膜炎的诊断价值。对于早期预测亚临床绒毛膜羊膜炎,检测妊娠妇女血清的生物指标具有相对无创、精确及快捷的优点,受到越来越多临床工作者的认可。随着炎性细胞因子研究的进展,检测相关血清指标有望成为临床可靠易行的早期诊断依据。
Chorioamnionitis secondary to unproductive premature rupture of membranes, and the close relationship with preterm birth. Because premature labor is the direct cause of death of more than 3/4 neonates, it should be highly vigilant chorioamnionitis, especially subclinical chorioamnionitis is neglected. A large number of literatures have studied the diagnostic value of traditional biological indexes including erythrocyte sedimentation rate, white blood cell count, C-reactive protein, and modern molecular biological indicators including matrix metalloproteinase, interleukin and tumor necrosis factor on chorioamnionitis. For the early prediction of subclinical chorioamnionitis, the detection of serum biomarkers in pregnant women is relatively noninvasive, accurate and quick. It is recognized by more and more clinical workers. With the progress of inflammatory cytokines, the detection of serum-related indicators is expected to become a reliable basis for early diagnosis of clinical reliable.