在细胞生长和代谢中铁起着很重要的作用。1945年发现血浆中大部份酸溶性铁离子是由一种特殊的金属结合蛋白运输,命名为铁传递蛋白Tarns-ferrin(Tf)。Tf是肝脏合成的一种糖蛋白,分子量为77,000。盘曲成二个对称的亚单位,称为N~-区和C~-区,每区可结合一个铁离子。用核磁共振法测定Tf的铁结合部位有2个酪氨酸2个组氨酸。 Iron plays an important role in cell growth and metabolism. In 1945 it was discovered that most of the acid-soluble iron ions in plasma were transported by a specific metal binding protein and named the ferritin Tarns-ferrin (Tf). Tf is a glycoprotein synthesized by the liver and has a molecular weight of 77,000. It is coiled into two symmetrical subunits, called N~-zone and C~-zone. Each zone can be combined with one iron ion. The iron binding site of Tf was determined by nuclear magnetic resonance to have 2 tyrosines and 2 histidines.