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目的研究PCNA、p53、MMP-2的表达与胃癌侵袭性与增殖性的关系。方法应用免疫组织化学SP法检测60例胃癌组织中3种指标的表达。结果 60例胃癌组织中PCNA、p53、MMP-2阳性表达率分别为60.0％、45.0％、38.3％;随肿瘤分化程度降低、分期进展、淋巴结的转移,PCNA、MMP-2阳性表达率逐渐升高,但p53与临床各参数之间无相关。结论PCNA、MMP-2可作为评估胃癌预后的独立指标;p53在判断胃癌预后方面没有意义。
Objective To study the relationship between the expression of PCNA, p53, MMP-2 and the invasiveness and proliferation of gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of three indexes in 60 cases of gastric cancer. Results The positive rates of PCNA, p53 and MMP-2 in 60 cases of gastric carcinoma were 60.0%, 45.0% and 38.3%, respectively. With the decreasing of tumor differentiation, staging and lymph node metastasis, the positive rate of PCNA and MMP-2 gradually increased High, but there is no correlation between p53 and clinical parameters. Conclusion PCNA and MMP-2 can be used as independent indexes to evaluate the prognosis of gastric cancer. P53 has no significance in judging the prognosis of gastric cancer.