有关中枢γ-氨基丁酸(GABA)能系统参与各种行为以及精神药物作用机理的问题,近年已进行大量研究。许多作者指出,在各种脊椎动物包括人类,GABA 能系统可能与阿片剂的作用及耐受性有关。阿片类镇痛药及其拮抗剂的作用涉及多种神经递质,例如乙酰胆碱、去甲肾上腺素、多巴胺、5-羟色胺以及内源性阿片 In recent years, a large number of studies have been conducted on the issue of the central GABAergic system being involved in various behaviors and the mechanism of action of psychotropic drugs. Many authors point out that the GABAergic system may be involved in the role and tolerance of opiates in a variety of vertebrates, including humans. The effects of opioid analgesics and their antagonists involve a variety of neurotransmitters, such as acetylcholine, norepinephrine, dopamine, serotonin and endogenous opioids