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目的 探讨喘息型支气管肺炎血清肿瘤坏死因子(TNF)、白细胞介素 8(IL 8)与病因、病程之间的关系。方法 ELISA法测定 35例患儿血清TNF、IL 8和肺炎支原体抗体 (MP IgM ,IgG) ;用桥联酶标法检测鼻咽部脱落细胞病毒抗原。对照组测其血清TNF、IL 8。结果 35例血清TNF、IL 8均高于对照组 (P <0 .0 5 )。病毒阳性检出率 5 1.4%,MP IgM阳性检出率 2 2 .8%。两组血清TNF、IL 8比较无显著性差异。病程长者血清TNF比病程短者高。结论 TNF、IL 8参与喘息型支气管肺炎的发病过程 ,其水平与病因无相关关系。病程长者TNF水平高 ,提示患儿气道炎症反应重。对此类患儿需要采取抗哮喘治疗。
Objective To investigate the relationship between serum tumor necrosis factor (TNF), interleukin 8 (IL 8) and etiology and course of disease in asthmatic bronchial pneumonia. Methods Serum TNF, IL 8 and Mycoplasma pneumoniae antibodies (MP IgM, IgG) in 35 children were detected by ELISA. The antigen of nasopharyngeal exfoliated virus was detected by enzyme linked immunosorbent assay. The control group measured serum TNF, IL 8. Results 35 cases of serum TNF, IL 8 were higher than the control group (P <0.05). The positive rate of virus was 54.4% and the positive rate of MP IgM was 22.8%. Serum TNF, IL 8 no significant difference between the two groups. Elderly disease serum TNF higher than the duration of the disease. Conclusion TNF and IL-8 are involved in the pathogenesis of asthmatic bronchopneumonia and their levels are not related to the etiology. TNF levels of elderly patients with high levels, suggesting that children with severe airway inflammation. For such children need to take anti-asthma treatment.