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目的:检测新型冠状病毒肺炎（COVID-19）患者血清心肌损伤标志物、凝血指标及炎性标志物的表达水平，探讨其在患者预后中的预测价值。方法:回顾性分析2020年2月1日至3月31日收入华中科技大学同济医院中法新城院区的COVID-19患者67例，按照病情严重程度分为普通组（n n=20）、重型组（n n=20）及危重组（n n=27），根据患者出院情况将危重组分为治愈（n n=12）和死亡（n n=15）。以患者好转出院或住院期间死亡作为观察终点。收集患者的临床资料，采集患者静脉血并检测其血液中超敏肌钙蛋白I（hs-cTnI）、肌红蛋白（MYO）、肌酸激酶同工酶MB（CK-MB）、N末端B型利钠肽原（NT-proBNP）、D-二聚体、凝血酶原时间（PT）、活化部分凝血活酶时间（APPT）、纤维蛋白原（FIB）、白细胞计数（WBC）、超敏C反应蛋白（hs-CRP）、铁蛋白水平，比较3组间的水平差异。采用多元logistic回归模型分析COVID-19住院患者死亡相关危险因素。n 结果:3组患者的红细胞、血小板（PLT）、FIB、血红蛋白差异均无统计学意义（n P>0.05），而普通组、重型组和危重组的WBC、hs-CRP、铁蛋白、PT、APPT及D-二聚体水平比较，差异有统计学意义（n P<0.05），危重组高于重型组和普通组（n P<0.05）。危重组患者NT-proBNP、CK-MB、MYO、hs-cTnI明显高于普通组及重型组，且危重型组中死亡患者NT-proBNP、CK-MB、MYO、hs-cTnI高于治愈患者（n P均n 0.05). However, the levels of WBC, hs-CRP, ferritin, PT, APPT and D-dimer in the normal group, the severe group and the critical recombination group were significantly different (n P<0.05), and the critical recombination group was higher than that of the severe group and the ordinary group (n P<0.05). NT-proBNP, CK-MB, MYO, hs-cTnI of critical patients were significantly higher than those of normal group and severe group, and pro BNP, CK-MB, MYO, hs-cTnI of death patients in critical severe group were higher than those of cured patients (alln P<0.05). Multivariate logistic regression analysis showed that the increase of hs-cTnI (n OR=1.053, 95%n CI 1.010-1.098, n P=0.016) and D-dimer (n OR=1.253, 95%n CI 1.026-1.531, n P=0.005) were the risk factors of death in patients with COVID-19.n Conclusion:COVID-19 critical and severe patients were accompanied with coagulation dysfunction and the increase of inflammatory factors. There were different degrees of myocardial injury, and the increase of hs-cTnI and D-dimer are the risk factors of death in patients with severe COVID-19.