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前言自1977年发表了一篇有关萘啶羧酸类抗菌剂的构效关系、微生物学和化学合成的综述之后,各种文献又报道5000多种新的类似物。近年来,发现了许多临床上有重要价值的抗菌剂,它们的化学结构中皆含有1-取代-1,4-二氢-4-氧-吡啶-3-羧酸,即通常称作喹诺酮类。这些新抗菌剂包括氟哌酸(Norfloxacin,1)、甲氟哌酸(Pefloxacin,2)、氟嗪酸(Ofloxacin,3)、环丙氟哌酸(Ciprofloxacin,4)、氟啶酸(Enoxacin,5)、双氟哌酸(Difloxacin,6)Temafloxacin(7)、Lomefloxacin(8)、Fleroxacin(9)、Tosu floxacin(10)和氨氟哌酸(Amifloxacin,
Preface Since 1977, an overview of the structure-activity relationship, microbiology and chemical synthesis of naphthyridinecarboxylic acid antibacterials has been published, and various literature reports more than 5,000 new analogues. In recent years, many clinically important antibacterial agents have been found which all contain 1-substituted-1,4-dihydro-4-oxo-pyridine-3-carboxylic acids in their chemical structure, . These new antibacterial agents include Norfloxacin (1), Pefloxacin (2), Ofloxacin (3), Ciprofloxacin (4), Enoxacin 5, Difloxacin 6, Temafloxacin 7, Lomefloxacin 8, Fleroxacin 9, Tosu floxacin 10, and Amifloxacin