正己烷是引起周围神经疾患的一种溶剂。有几次假设其毒性可能是通过代谢产物起作用的。因此研究了己烷主要的代谢产物—己醇—1和己醇—2的神经毒性。给大鼠皮下注射化合物8个月。己醇—1对周围神经系统产生的神经毒性症状是可疑的。己醇—2引起了神经生理和组织学上可证实的周围神经病。该神经病与正己烷、甲基正丁酮和2,5—hexanedione在实验多发性种经炎中所观察到的一样。因此,己醇—2可认为是与正己烷和 Hexane is a solvent that causes peripheral neuropathy. Several times assume that its toxicity may be through metabolites. Thus, the neurotoxicity of Hexanol-1 and Hexanol-2, the major metabolites of hexane, was studied. The rats were injected subcutaneously with the compound for 8 months. Hexanol-1 is suspected of causing neurotoxic symptoms in the peripheral nervous system. Hexanol-2 elicits neurophysiologically and histologically verifiable peripheral neuropathy. This neuropathy is the same as n-hexane, methyl-n-butanone and 2,5-hexanedione found in experimental polyphenols. Therefore, hexanol-2 can be considered with n-hexane and