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本文报导从旋花科牵牛属植物Ipomoea leari Paxt.中分到一种新甙ipolearoside,对大鼠有抗瓦克氏癌256的作用,并经结构测定,证明ipolearoside为3,11-二羟基十六酸和葡萄糖、鼠李糖及岩藻糖(Fucose)的复合甙。 Ipolearoside的分离:干燥全植物的粉末,用95%乙醇渗漉,渗漉液在50°以下减压浓缩除去溶剂后,所得的粘稠状固体,依次用乙烷、氯仿、丙酮捏溶抽提。经此处理后的不溶物质,以乙醇溶解后滤除杂质,蒸干,再通过硅胶柱层析,从氯仿-甲醇(3∶1)洗脱部分,得一淡棕色吸湿性固体,用少量甲醇溶解后加乙醚沉淀,反复三次,得淡白色无定形粉末,
This article reports from the Ilex parvacea Ipomoea leari Paxt. Division of a new glycosides ipolearoside, against Wacker’s cancer 256 in rats and structural determination, that ipolearoside 3,11-dihydroxy Palmitic acid and glucose, rhamnose and fucose compound glycosides. Isolation of Ipolearoside: The whole plant powder was dried and percolated with 95% ethanol. After the percolate was concentrated under reduced pressure at 50 ° C to remove the solvent, the resulting viscous solid was extracted with hexane, chloroform and acetone . The insolubles thus treated were dissolved in ethanol to remove impurities and evaporated to dryness. The residue was eluted from chloroform-methanol (3: 1) by silica gel column chromatography to give a pale brown hygroscopic solid which was washed with a small amount of methanol Dissolved in ether after precipitation, repeated three times, have pale white amorphous powder,