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目的评价根除幽门螺杆菌治疗特发性血小板减少性紫癜的临床疗效。方法检索1998年1月至2010年10月PubMed、EMbase、CNKI、维普中文科技期刊数据库等,纳入有关抗Hp方案治疗ITP的RCT。按Meta分析方法提取有效数据,用RevMan5.0.24软件对结局指标进行Meta分析。结果共纳入11个RCT,包括605例患者。Meta分析结果显示:实验组的总有效率高于对照组[OR=3.96,95%CI(2.52,6.23),P<0.000 01];实验组治疗3、6个月后血小板升高程度高于对照组,差异有统计学意义(P<0.000 01);实验组的复发率低于对照组[OR=0.21,95%CI(0.09,0.46),P=0.000 01]。结论抗Hp治疗ITP可提高治疗有效率,并能降低复发率,可作为治疗ITP有效可行的方法。
Objective To evaluate the clinical efficacy of eradication of Helicobacter pylori in the treatment of idiopathic thrombocytopenic purpura. METHODS: From January 1998 to October 2010, PubMed, EMbase, CNKI and VIP Chinese Sci-tech periodical databases were searched for RCTs for anti-Hp regimen in the treatment of ITP. Meta analysis method to extract valid data, using RevMan5.0.24 software for the outcome of the Meta-analysis. Results A total of 11 RCTs were included, including 605 patients. The results of Meta-analysis showed that the total effective rate of the experimental group was higher than that of the control group [OR = 3.96,95% CI (2.52,6.23, P <0.000 01]. The experimental group had higher thrombocytopenia The difference was statistically significant (P <0.000 01). The recurrence rate in the experimental group was lower than that in the control group [OR = 0.21, 95% CI (0.09, 0.46), P = 0.000 01]. Conclusion Anti-Hp treatment of ITP can improve the treatment efficiency and reduce the recurrence rate, which can be used as a effective and feasible method for the treatment of ITP.