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肝素的定量方法有很多,有关抗凝血的检验方法包括血液学方法和药物学方法。药物学方法中的体外凝结测定方法又有若干种,其中为美国药典14版沿用至今的,Reinert等创始的重钙化羊血浆法,准确性较高,重现性好,操作简便,测定时间短,因此成为目前国际上广泛采用的肝素效价测定方法。而在这种测定中,柠檬酸羊血浆的制备是测定成功的关键性问题之一。有关血浆分离的技术问题至今仍未见有专门研究。在适应
There are many quantitative methods of heparin, blood test methods and hematological methods and pharmacological methods. There are several other methods for the determination of in vitro coagulation in pharmacological methods. Among them are the re-calcification sheep plasma method initiated by Reinert et al.14, which has been used to date, with high accuracy, good reproducibility, easy operation and short measuring time , So it has become widely used in the international heparin potency determination method. In this assay, the preparation of citrated goat plasma is one of the key issues in the success of the assay. There have been no technical studies on plasma separation so far. Adapt