论文部分内容阅读
目的探讨基于D2SRS微型光栅对于早期非小细胞肺癌体部立体定向放射治疗的计划设计及临床应用的可行性。方法选取2015年6月至2016年1月间石家庄市第一医院收治的2例早期非小细胞肺癌患者,基于调强放疗技术(intensity-modulated radiation therapy,IMRT)设计体部立体定向放射治疗计划,分析对比Elekta Synergy VMAT 10mm多叶光栅与D2SRS 2mm微型光栅2种计划模式下靶区和危及器官所接受的剂量。结果基于D2SRS 2mm微型光栅的治疗计划与目前临床常规应用的ELekta Synergy VMAT 10mm多叶光栅计划相比进一步优化了治疗计划质量,适形度及均匀度提高,肺和脊髓等危及器官中剂量降低了。结论 D2SRS微型光栅系统可以用于早期肺癌体部立体定向放射治疗,其2mm的等中心叶片厚度相对于10mm多叶光栅计划,对靶区有更好的适形性和剂量跌落梯度,危及器官的剂量更低。
Objective To investigate the feasibility of planning and clinical application of stereotactic radiosurgery for early non-small cell lung cancer based on D2SRS microdissection grating. Methods Two patients with early stage non-small cell lung cancer who were admitted to Shijiazhuang No.1 Hospital from June 2015 to January 2016 were enrolled in this study. The body stereotactic radiotherapy program was designed based on intensity-modulated radiation therapy (IMRT) , Analyzed and compared the doses received by the target and endangered organs under the two planned modes of Elekta Synergy VMAT 10mm multi-leaf grating and D2SRS 2mm micro-grating. Results The treatment plan based on the D2SRS 2mm microribit further optimizes the quality, conformability and uniformity of the treatment plan compared with the current clinical routine ELekta Synergy VMAT 10mm multi-leaf gratings program, with dose reductions in organs at risk of lung and spinal cord . Conclusions The D2SRS micro-grating system can be used for stereotactic radiosurgery in early stage of lung cancer. The 2mm isocenter leaf thickness has better conformality and dose drop gradient to the target area than the 10mm multi-leaf grating plan, Lower doses.