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目的:评价注射用五水头孢唑林钠对妇产科感染患者的临床疗效和安全性。方法:选取2013年5月—2015年2月间妇产科收治的感染患者360例作为研究对象,采用随机数字表法将其分为观察组和对照组,每组180例;观察组患者给予注射用五水头孢唑林钠治疗,对照组患者给予注射用头孢他啶治疗;评价两组患者治疗后的总有效率和药物不良反应的发生情况。结果:观察组患者治疗后的总有效率为97.22%显著高于对照组为89.44%(t=8.750,P<0.05);转阴清除率为93.89%(169/180)明显高于对照组为76.11%(137/180)(t=22.309,P<0.05);药物不良反应发生率为3.89%明显低于对照组为11.11%(t=6.767,P<0.05)。结论:注射用五水头孢唑林钠用于治疗妇产科感染患者的临床疗效优于注射用头孢他啶治疗,且有效提高了治愈率,减少了不良反应的发生。
Objective: To evaluate the clinical efficacy and safety of cefazolin sodium pentaspirone injection in obstetrics and gynecology patients. Methods: A total of 360 patients with infectious diseases admitted to the department of gynecology and obstetrics from May 2013 to February 2015 were selected as the study subjects, and divided into observation group and control group with 180 cases in each group by random number table method. Patients in observation group were given Injection of cefazolin sodium pentahydrate treatment, patients in the control group were given ceftazidime injection therapy; evaluation of two groups of patients after treatment, the total effective rate and adverse drug reactions. Results: The total effective rate of the observation group after treatment was 97.22%, which was significantly higher than that of the control group (89.44%, t = 8.750, P <0.05). The negative clearance rate was 93.89% (169/180) 76.11% (137/180) (t = 22.309, P <0.05). The adverse drug reaction rate was 3.89%, which was significantly lower than that of the control group (11.11%, t = 6.767, P <0.05). Conclusion: Cefazolin sodium pentahydrate for the treatment of obstetrics and gynecology patients with clinical efficacy is superior to injection of ceftazidime treatment, and effectively improve the cure rate and reduce the incidence of adverse reactions.