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目的观察脑梗死患者急性期血清中可溶性细胞间粘附分子－ 1(ICAM－ 1)的含量变化及临床意义。方法采用双抗体夹心 ELISA法测定血清 ICAM－ 1含量。结果脑梗死组及危险因素组血清中 ICAM－ 1含量明显高于对照组。结论血清可溶性 ICAM－ 1水平的升高与脑卒中危险因素的存在有关，反映血管内皮存在炎症性活化，脑梗死伴发炎症反应，炎症反应参与脑缺血性损伤。
Objective To observe the changes of serum soluble intercellular adhesion molecule - 1 (ICAM - 1) in patients with acute cerebral infarction and its clinical significance. Methods Serum ICAM-1 levels were measured by double antibody sandwich ELISA. Results Serum ICAM-1 levels in cerebral infarction group and risk group were significantly higher than those in control group. Conclusions The increase of soluble ICAM - 1 in serum is related to the existence of risk factors of stroke. It reflects the existence of inflammatory activation in vascular endothelium, cerebral infarction with inflammatory reaction and inflammatory reaction in cerebral ischemic injury.