硬皮病是波及皮肤的一种结缔组织病 ,分局限性和系统性两种类型 ,前者主要表现为局部皮肤硬化 ,皮肤变硬发亮 ,或皮肤发暗呈褐色 ,甚至皮肤萎缩 ;后者除皮损外 ,并可累及内脏器官。由于本病病因尚未十分明了 ,且出现多系统的功能损害 ,病程冗长 ,缠绵难愈 ,所以说该病又称顽固 Scleroderma is a connective tissue disease affecting the skin, sub-regional and systemic two types, the former mainly for the local skin sclerosis, the skin becomes hardened and shiny, or dark brown skin, and even the skin atrophy; the latter In addition to skin lesions, and can affect the internal organs. As the etiology of the disease is not yet very clear, and the emergence of multi-system dysfunction, long duration, lingering hard to cure, so that the disease is also called stubborn