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农吉利硷对人肝癌细胞株长期影响的观察进一步证明,这种药物对该细胞株影响的主要表现是细胞体积增大,有丝分裂下降,畸变和多核巨细胞增多以及细胞空泡变性、固缩、破碎死亡。这种影响的程度随着药物浓度的加大和作用时间的延长而加剧。停药后各组细胞继续退变脱落,但在17天之后在残留的退变细胞之间,出现梭形小细胞,这种细胞逐渐增多生长为多边形细胞呈片状分布,形态上与未加药对照组无异。这些细胞很可能来自残存的极少数多边形上皮样细胞(Go期细胞或者对药物不敏感细胞)分裂产生的。这种细胞的存在可能是化疗或放疗后复发的原因。
The long-term effects of NGI on human hepatoma cell lines further demonstrated that the main effects of this drug on the cell line are increased cell volume, decreased mitosis, distortion and multinucleated giant cell increase, and cell vacuolar degeneration, pyknosis, Broken to death. The extent of this effect is exacerbated by the increase in drug concentration and the prolonged duration of action. After discontinuation of treatment, the cells in each group continued to degenerate and fall off, but after 17 days, fusiform cells appeared between the degenerating cells that remained, and the cells gradually grew into polygonal cells in a sheet-like distribution, with and without morphology. Drug control group is no different. These cells are most likely derived from the division of a remnant of very few polygonal epithelioid cells (Go-phase cells or drug-insensitive cells). The presence of this cell may be the cause of relapse after chemotherapy or radiotherapy.