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目的分析慢性泪囊炎感染患者病原菌分布及药敏试验结果,为临床合理选择抗菌药物提供依据。方法选取2010年1月-2015年1月医院收治的慢性泪囊炎感染患者156例,分析感染病原菌分布及其耐药率,数据采用SPSS13.0软件进行统计分析。结果 156例慢性泪囊炎感染患者送检标本中98份标本阳性,阳性率为62.82%;共检出病原菌98株,其中革兰阳性球菌72株、革兰阴性杆菌21株、革兰阳性杆菌2株、革兰阴性球菌1株、真菌2株,分别占73.47%、21.43%、2.04%、1.02%和2.04%;革兰阳性球菌主要对万古霉素、庆大霉素、左氧氟沙星和头孢哌酮/舒巴坦最为敏感,敏感率分别为94.44%、90.28%、91.67%和90.28%;革兰阴性杆菌对头孢哌酮/舒巴坦、左氧氟沙星、亚胺培南和美罗培南最为敏感,敏感率分别为95.24%、90.48%、95.24%和90.48%。结论慢性泪囊炎感染患者病原菌以革兰阳性球菌和革兰阴性杆菌为主,由于慢性泪囊炎易反复发作导致病原菌耐药增加,应重视慢性泪囊炎患者的耐药性,为取得更好的临床疗效,应根据药敏试验结果合理选择抗菌药物治疗。
Objective To analyze the distribution of pathogenic bacteria in patients with chronic dacryocystitis infection and the results of drug susceptibility test, so as to provide a basis for clinical rational selection of antimicrobial agents. Methods 156 patients with chronic dacryocystitis admitted from January 2010 to January 2015 in our hospital were selected for analysis of the distribution of pathogens and their drug resistance rate. The data were analyzed by SPSS 13.0 software. Results A total of 98 specimens were positive in 98 samples of 156 cases with chronic dacryocystitis infection. The positive rate was 62.82%. 98 strains of pathogens were detected, including 72 strains of Gram-positive cocci, 21 strains of Gram-negative bacilli, 2 strains, 1 strain of Gram-negative cocci and 2 strains of fungi, accounting for 73.47%, 21.43%, 2.04%, 1.02% and 2.04%, respectively. Gram-positive cocci were mainly resistant to vancomycin, gentamicin, levofloxacin and cefoperazone Ketone / sulbactam was the most sensitive, the sensitivity rates were 94.44%, 90.28%, 91.67% and 90.28% respectively. Gram-negative bacilli were the most sensitive to cefoperazone / sulbactam, levofloxacin, imipenem and meropenem, Respectively 95.24%, 90.48%, 95.24% and 90.48%. Conclusions Chlamydia pneumoniae and Gram-negative bacilli are the main pathogens in patients with chronic dacryocystitis infection. Due to repeated episodes of chronic dacryocystitis, drug resistance of pathogens is increased, and drug resistance of patients with chronic dacryocystitis should be emphasized. Good clinical efficacy, should be based on drug susceptibility test results reasonable choice of antimicrobial therapy.