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目的 探讨经右心房快速起搏建立急性兔房颤模型的可行性.方法 24只新西兰大耳白兔随机分为起搏组(n=12)和对照组(n=12).两组均经颈静脉植入10极冠状窦电极,但对照组不起搏.起搏组通过快速右心房起搏和程控刺激相结合方法诱导急性房颤,对起搏各时间段心房有效不应期,心房有效不应期适应性及房颤诱发情况和持续时间进行观测.结果 起搏组11只兔子诱发出急性房颤,房颤诱发成功率为91.67％;心房有效不应期缩短,心房有效不应期频率适应不良,与自身基础状态相比有差异有统计学意义(P＜0.05);对照组未出现房颤.实验过程中兔血流动力学稳定.结论 这种新型的动物模型房颤诱发成功率高,制作方法简便、易于掌握和推广,可用于房颤发病机理、电生理重构、心肌重构、分子生物学改变等研究.“,”Objective To explore the feasibility of establishing a rabbit model of acute atrial fibrillation by method of rapid right atrial pacing.Methods 24 New Zealand white rabbits were randomly divided into 2 equal groups:pacing group and control group.All rabbits underwent implantation of a 10-polar sinus electrode into the right atrium via jugular vein.Acute atrial fibrillation was induced by combination of rapid right atrial pacing and programmed stimulation in the pacing group.In each time period of pacing,the atrial effective refractory period (AERP),adaptability of AERP,and induced conditions and duration of atrial fibrillation were measured and recorded.Results Acute atrial fibrillation was induced in 11 rabbits of the pacing group,with a success rate of 91.67％.Compared to those baseline situations,the AERP was shortened,and the frequency adaptation of AERP became poorer,both significantly (both P ＜0.05) in the pacing group.However,atrial fibrillation did not appear in the control group.During the experiment,all rabbits maintained hemodynamic stability.Conclusion With a higher success rate,lower cost,and simpler operation,this new method of implantation of 10-polar sinus electrode into the right atrium via jugular vein and then combination of rapid right atrial pacing and programmed stimulation is superior to the old methods such as drug induction and implantation of pacemaker by open-heart surgery on bigger animals,such as dogs,pigs,and goats,in research of the pathogenesis of atrial fibrillation and other physiological problems.