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创立了复方甲硝唑注射液中氯霉素和甲硝唑的衍生光谱快速测定法。用计算机Excel绘制氯霉素和甲硝唑的衍生光谱,选择其峰点236.0 nm和交点223.0 nm为测定波长,可排除两组分的互相干扰,直接测定复方甲硝唑注射液中两组分的含量。氯霉素的比耳线性范围为(9.890～32.13)μg/mL,r=0.9995;甲硝唑为(10.09～30.28)μg/mL,r=0.9992。氯霉素和甲硝唑的平均回收率和相对标准偏差分别100.4%,1.3%和100.8%,0.68%。新方法简便、快速、准确,适用于医院制剂复方甲硝唑注射液的质量检测。
Established the metronidazole compound metronidazole injection chloramphenicol and metronidazole rapid determination of the spectrometry. The derivation spectra of chloramphenicol and metronidazole were drawn by computer Excel. The peak at 236.0 nm and the intersection at 223.0 nm were selected as the determination wavelength, and the mutual interference between the two components could be eliminated. The direct determination of the two components in compound metronidazole injection Content. The linear range of chloramphenicol was (9.890 ~ 32.13) μg / mL, r = 0.9995; metronidazole was (10.09 ~ 30.28) μg / mL, r = 0.9992. The average recoveries and relative standard deviations of chloramphenicol and metronidazole were 100.4%, 1.3% and 100.8%, 0.68%, respectively. The new method is simple, rapid and accurate, suitable for the quality control of compound metronidazole injection in hospital.